Russian and Syrian air raids on the rebel-held eastern half of the city of Aleppo have forced the closure of the largest hospital in the area and killed two people, a medical charity says.
The Syrian American Medical Society, which supports the hospital, said it had been struck by barrel bombs.
There are also reports of Russian-backed Syrian government forces hitting Aleppo's historic Old City.
Clashes between government troops and rebels are occurring in several areas.